Best of the AANS Session-B-cell Lymphoma 2 (BCL2) Single Nucleotide Polymorphism (rs17759659) Is Associated With Intracranial Hypertension

B-cell Lymphoma 2 (BCL2) Single Nucleotide Polymorphism (rs17759659) Is Associated With Intracranial Hypertension

Video Transcription

Video Summary

The video features Hanson Dame, a neurosurgery resident at the University of Pittsburgh, discussing his research on the association between the B-cell lymphoma 2 (BCL2) gene and increased intracranial pressure (ICP) after severe traumatic brain injury (TBI). The study analyzed patients with severe TBI and found that possession of the variant allele of the BCL2 SNP RS17759659 resulted in worse functional outcomes at three months post-injury. Patients with the variant allele had higher mean ICP, more spikes in ICP over 20, increased risk of radiographic edema, and a higher need for surgical decompression. The study suggests that BCL2 polymorphisms may impact ICP and edema development following severe TBI.

Keywords

Hanson Dame

neurosurgery resident

B-cell lymphoma 2 gene

intracranial pressure

traumatic brain injury