Cerebrovascular Session-Establishing A Clinically Relevant Animal Model of Intracerebral Hemorrhage_ Investigating The Effect Of Hypertension

Establishing A Clinically Relevant Animal Model of Intracerebral Hemorrhage_ Investigating The Effect Of Hypertension

Video Transcription

Video Summary

In this video, Anthony Anzalone, a third-year medical student at Wake Forest School of Medicine, presents his research on establishing a clinically relevant animal model of intracerebral hemorrhage (ICH) and investigating the effect of hypertension, metabolic syndrome, and sex on the histologic and sensory motor response. He highlights the lack of progress in developing effective treatments for ICH and the limitations of current preclinical models. By utilizing the REN2 transgenic rat, which develops chronic hypertension and features of metabolic syndrome, Anzalone aims to create a more accurate model that mirrors the comorbidities of ICH patients. He discusses the preliminary findings regarding blood pressure and sensory motor testing, and plans to further analyze histologic and immunohistochemical profiles to identify potential therapeutic targets for ICH. Anzalone gives credit to his mentor, Dr. Stacy Wolf, and acknowledges the DEVIL-ANS Virtual Cerebrovascular Session for the opportunity to present his work.

Keywords

intracerebral hemorrhage

hypertension

metabolic syndrome

animal model

sensory motor response