Neurosurgery in Press: Latest Results of Clinical Trials in Neurosurgery and Allied Fields-Neurosurgery In Press 2021, Stereotactic & Functional Neurosurgery Update

Video Transcription

Video Summary

In this video transcript, Dr. Aviva Yabash, a professor of Neurosurgery and Chairman of the Department of Neurosurgery at the University of Nebraska Medical Center, discusses ongoing clinical trials in the field of stereotactic and functional neurosurgery. She starts by reflecting on the impact of the COVID-19 pandemic on surgical volume and the pipeline of patients for clinical trials. Dr. Yabash then focuses on specific clinical trials in the treatment of Parkinson's disease, epilepsy, dementia, and tinnitus.<br /><br />For Parkinson's disease, she discusses the use of gene therapy trials, specifically the AADC enzyme and the VYA-AADC vector. She explains the improvements in targeting and delivery techniques and the promising results of the Phase 1B trial. However, the subsequent Phase 2 trial called Restore-1 is currently on hold due to MRI abnormalities observed in some participants.<br /><br />In terms of epilepsy treatment, Dr. Yabash mentions the SLATE trial for laser ablation but states that there is no data to report yet. She then focuses on the use of deep brain stimulation in the fornix for dementia treatment, discussing the ADVANCE-1 trial and its positive outcomes in terms of increased cerebral glucose metabolism and potential slowing of cognitive decline.<br /><br />Lastly, Dr. Yabash talks about caudate stimulation for tinnitus and the positive results seen in a pilot project. She mentions an ongoing open-label trial to refine targeting based on functional imaging.<br /><br />Overall, Dr. Yabash acknowledges the need for further research and urges viewers to stay tuned for updates on these clinical trials.

Keywords

Clinical trials

Parkinson's disease

Gene therapy

Epilepsy

Dementia treatment

Tinnitus