New Neurons: The Future of Regenerative Therapy-Gary K. Steinberg, MD, PhD, FAANS Video

Video Transcription

Video Summary

The video transcript is a presentation by Gary Steinberg from Stanford University. He discusses the use of stem cell therapy for stroke. Steinberg explains that they started studying this therapy in the laboratory 20 years ago by transplanting human fetal neural cells into rats after a stroke. They found that the cells migrate to the stroke area and express chemokine receptors that interact with chemicals released by the stroke environment. The cells secrete trophic factors and enhance native mechanisms of recovery like axonal sprouting and angiogenesis. Steinberg mentions that there have been 24 clinical studies published, mostly using bone marrow-derived mesenchymal cells, and most of these studies are in early phases. He discusses the results of various clinical studies, some of which showed positive outcomes while others showed no significant benefits. He then focuses on a study they conducted using intracerebral stem cell transplantation in chronic stroke patients. The study involved 30 patients and showed significant improvements in neurological function. Steinberg presents case studies of patients who regained mobility and gave positive feedback on their recovery. He concludes by mentioning ongoing clinical trials and the need for further research and caution when considering stem cell therapy. No credits were mentioned in the video.

Keywords

stem cell therapy

stroke

Gary Steinberg

Stanford University

clinical studies

neural cells

trophic factors