Pain Session-Neuron-Glial Inflammasome Enhanced Reversal by DTM-SCS Relative to High Rate and Low Rate SCS in a Neuropathic Pain Model

Neuron-Glial Inflammasome Enhanced Reversal by DTM-SCS Relative to High Rate and Low Rate SCS in a Neuropathic Pain Model

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Video Summary

The video features William Smith, a second-year medical student at Dartmouth Geisel School of Medicine, presenting his research on spinal cord stimulation for neuropathic pain. He thanks the Scientific Committee and AANS for their support, as well as his mentors Dr. David Cedeno and Dr. Ricardo Vallejo. The research focuses on the use of differential-targeted multiplex spinal cord stimulation (DTM-SCS) to target different cell types in the spinal cord. It shows that DTM-SCS can reverse the effects of neuropathic pain more effectively than high-rate or low-rate stimulation in rat models and has potential clinical benefits. The study combines RNA sequencing and flow cytometry to analyze gene expression in inflammasomes, showing that DTM-SCS can rebalance these inflammatory pathways and improve behavioral outcomes.

Keywords

spinal cord stimulation

neuropathic pain

DTM-SCS

rat models

inflammasomes