AANS Online Scientific Session: Pediatrics-Targeting Neogenin as an Anti-invasive Therapy for Diffuse Intrinsic Pontine Glioma

Targeting Neogenin as an Anti-invasive Therapy for Diffuse Intrinsic Pontine Glioma

Video Transcription

Video Summary

In this video, a research fellow presents their work on targeting neogenin as an anti-invasive therapy for diffuse intrinsic pontine gliomas (DIPG). DIPG is a brain tumor with a high mortality rate in children and current treatment options are limited. The research shows that the protein NETREN1, which is elevated in tumors, promotes tumorigenesis and invasion in brain tumors. The study also finds that neogenin, a cell surface receptor, is highly expressed in DIPG cells and blocking its activity leads to a significant decrease in cell invasion. These findings suggest that neogenin could be a promising therapeutic target for DIPG treatment. Further research is needed to investigate the ligand and signaling pathways involved. The researcher acknowledges their research team and collaborators for contributing to the study.

Asset Subtitle

Julie Sesen

Keywords

neogenin

anti-invasive therapy

diffuse intrinsic pontine gliomas

DIPG

NETREN1