Plenary Session Abstracts and Discussant Presentations-Development of Cell-free DNA-based Liquid Biopsy for Early Diagnosis of Brain Injury

Development of Cell-free DNA-based Liquid Biopsy for Early Diagnosis of Brain Injury - Kathleen Ran, AB

Video Transcription

Video Summary

Kathleen Rann presented her research on a liquid biopsy for acute brain injury, focusing on methylation-based detection of brain-derived cell-free DNA. This approach aims to improve brain injury diagnostics and prognosis by correlating DNA levels with injury severity and six-month mortality. The digital droplet PCR assay demonstrated reliability in detecting brain injury and showed strong links to known biomarkers like S100B and UCHL1. Dr. Laura Nguyenia highlighted the study's potential to refine patient care by enhancing prognostic models, aiding in decision-making regarding life-support, and predicting recovery outcomes beyond mortality.

Keywords

liquid biopsy

brain injury

cell-free DNA

digital droplet PCR

biomarkers