Plenary Session Abstracts and Discussant Presentations-Dexamethasone Induced p57-Mediated Quiescence Contributes to Chemotherapy Resistance in Sonic Hedgehog Medulloblastoma

Dexamethasone Induced p57-Mediated Quiescence Contributes to Chemotherapy Resistance in Sonic Hedgehog Medulloblastoma - Aryaman Sharma, BSc

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Video Summary

Research on sonic hedgehog medulloblastoma reveals that quiescent tumor cells, driven by the p57 protein, resist standard therapies and cause recurrence due to their slow cycling rate. High p57 expression maintains cell quiescence, with p57 induction shown to cause cell cycle arrest and resistance to chemotherapeutic vincristin. Dexamethasone, used in neuro-oncology, increases p57 levels, potentially enhancing tumor cell resistance to therapies. This suggests the need for cautious use of dexamethasone, especially in patients with high-risk features like p53 mutations. Further studies are needed on how steroids influence treatment resistance and tumor cell quiescence.

Keywords

sonic hedgehog medulloblastoma

p57 protein

tumor cell quiescence

dexamethasone resistance

p53 mutations