Plenary Session Abstracts and Discussant Presentations-Single Nuclear RNA Sequencing of Pituitary Neuroendocrine Tumors Challenges Their Current Classification Schema

Single Nuclear RNA Sequencing of Pituitary Neuroendocrine Tumors Challenges Their Current Classification Schema - Robert Osorio, MD

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Video Summary

Dr. Robert Osorio presented UCSF's research on mapping pituitary neuroendocrine tumors using single nuclear RNA sequencing. The study revealed the existence of four plurihormonal cell clusters within the pituitary, challenging the current lineage-based classification. These tumors displayed significant heterogeneity, existing on a continuum rather than distinct subtypes. This finding suggests that pituitary tumors might originate from different precursor cells, leading to varied phenotypes and outcomes. The study underscores the potential for a new classification system based on genetic and developmental insights, which could inform more effective treatment strategies. Dr. Galare Zadeh highlighted the importance of integrating genomic data to enhance tumor classification and treatment.

Keywords

pituitary neuroendocrine tumors

single nuclear RNA sequencing

plurihormonal cell clusters

tumor heterogeneity

genomic data integration