Technological Adjuncts for Malignant Brain Tumor Surgery-Constantinos G. Hadjipanayis, MD, PhD, FAANS Video

Video Transcription

Video Summary

The video transcript discusses the current standard of care for high-grade glioma, which involves maximal safe resection. However, due to the invasive nature of gliomas, achieving maximum resection is challenging. The limited FDA-approved drug list for high-grade gliomas consists of only six drugs and two devices, one of which is Temozolomide. The use of fluorescence-guided surgery is explored as a technology to help surgeons visualize tumor tissue in real-time and improve resection accuracy. Different agents, such as fluorescein sodium and indocyanine green, are mentioned for their potential in fluorescence-guided surgery. The focus later shifts to 5-ALA compound, which is being widely used in many centers with positive outcomes. The approval of 5-ALA took several years and it is currently being investigated for different applications, including intraoperative therapy and combination with other imaging modalities. The use of fluorescence-guided surgery in pediatric tumors is also briefly discussed. Overall, fluorescence-guided surgery shows promise in improving the extent of resection and patient outcomes in high-grade gliomas.

Keywords

high-grade glioma

maximal safe resection

fluorescence-guided surgery

visualization

tumor tissue

patient outcomes