AANS Online Scientific Sessions: Tumor-Distinct Regional Activity And Ontogeny Of Tumor Associated Macrophages In Human Glioblastoma Suggests Parallel Recruitment Processes.

Distinct Regional Activity And Ontogeny Of Tumor Associated Macrophages In Human Glioblastoma Suggests Parallel Recruitment Processes.

Video Transcription

Video Summary

The video features Joel Zador, a neurosurgery fellow at St. Michael's Hospital, University of Toronto, discussing regional differences in macrophage recruitment and activation in glioblastoma. He explains that glioblastoma is a lethal brain tumor and despite current treatments, survival rates are low. Zador highlights the potential of targeting immune cells, specifically macrophages, to improve treatment outcomes. He presents research on the different roles of macrophages in different regions of the tumor, explaining that in the tumor core, bone marrow-derived macrophages are more abundant and promote inflammation, while in the periphery, microglia-derived macrophages associate with non-inflammation and NF-kappa-b signaling. These findings suggest the need for a multi-targeted approach to glioblastoma therapeutics. The research was sponsored by the Michael and Amir Adan Fellowship.

Asset Subtitle

Zsolt Zador, MD, PhD

Keywords

macrophage recruitment

glioblastoma

treatment outcomes

immune cells

multi-targeted approach