AANS Online Scientific Sessions: Tumor-Epigenetic Modulation As A Novel Treatment Strategy for Chordoma

Epigenetic Modulation As A Novel Treatment Strategy for Chordoma

Video Transcription

Video Summary

In this video, Saqib Haque, a medical student at Johns Hopkins, discusses the potential of epigenetic modulation as a novel treatment strategy for Chordoma, a rare aggressive cancer of the spine and skull base. The current management for Chordoma involves surgical resection and adjuvant radiotherapy, but there are challenges due to the invasive nature, radio-resistance, and chemo-resistance of the cancer. Haque explains that recent studies have looked at the epigenetic landscape of Chordoma and found distinct patterns of DNA and histone methylation. He presents data from his own research, which explores the inhibitory effects of drugs targeting histone and DNA methylation on Chordoma cell growth, clonogenic potential, invasion, and cell death. The combination of these two strategies showed the most promising results. Haque concludes that epigenetic reprogramming could be a potential therapeutic strategy for Chordoma that warrants further investigation.

Asset Subtitle

Sakibul Huq

Keywords

epigenetic modulation

Chordoma

treatment strategy

DNA methylation

histone methylation