AANS Online Scientific Sessions: Tumor-Identification of 48 Novel Long Noncoding RNAs (lncRNAs) Modulating Glioblastoma Invasion via CRISPR-Interference Functional Screen

Identification of 48 Novel Long Noncoding RNAs (lncRNAs) Modulating Glioblastoma Invasion via CRISPR-Interference Functional Screen

Video Transcription

Video Summary

In this video, the speaker discusses the identification of non-coding RNAs with functional relevance in glioblastoma invasion. They explain that while previous studies have focused on protein target candidates for treatment, little attention has been given to the 80% of the genome known as long non-coding RNAs. These non-coding RNAs have significant functions in multiple cancers. The speaker explains the difficulty in determining the function of these non-coding RNAs and highlights the usefulness of CRISPR-I in assessing their function. They present the results of a massively parallel screen that identified several non-coding RNAs associated with invasion and growth phenotypes in glioblastoma. The study was supported by funding from the NIH-KL2 and the Margaret Early Foundation.

Asset Subtitle

Frank Joseph Attenello III, MD

Keywords

non-coding RNAs

functional relevance

glioblastoma invasion

long non-coding RNAs

CRISPR-I