AANS Online Scientific Sessions: Tumor-Modeling the Genetic, Transcriptomic, and Cell Surface Antigen Heterogeneity of Glioblastoma Using Patient Derived Tumor Organoids

Modeling the Genetic, Transcriptomic, and Cell Surface Antigen Heterogeneity of Glioblastoma Using Patient Derived Tumor Organoids

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Video Summary

The video transcript summarizes research on glioblastoma organoids, which are laboratory models of glioblastoma, an aggressive and deadly brain tumor. Glioblastoma is known for its heterogeneity within and between patients, both at the genetic and transcriptomic levels, leading to treatment resistance. The researchers developed a method to create glioblastoma organoids that capture this heterogeneity by culturing fresh tumor tissue. These organoids maintain the genetic and transcriptional landscapes of their parent tumors and preserve patient-specific gene expression signatures. They also maintain the cellular composition and microenvironment of the tumor, making them a valuable tool for studying tumor genesis, testing therapies, and advancing neuro-oncology research. The speaker acknowledges their mentors, collaborators, and funding sources. (194 words)

Asset Subtitle

Daniel Zhang

Keywords

glioblastoma organoids

laboratory models

brain tumor

heterogeneity

treatment resistance