Update on Tumors for the General Neurosurgeon II: Skull Base, Pediatric and Spine Tumors-Evolving concepts in understanding meningioma: 2019

Video Transcription

Video Summary

In this video, Dr. Link discusses the evolving understanding of meningioma and provides insights into the current research and clinical implications of this brain tumor. He highlights the changing nuances in the pathology of meningioma and shares his excitement about the ongoing reappraisal of how meningioma is conceptualized. Dr. Link discusses the heterogeneity of meningiomas and the need to consider evolving concepts and incorporate novel biologic information into the understanding and treatment of these tumors. He explores the World Health Organization (WHO) grading system and its limitations in accurately categorizing meningiomas, emphasizing the multifactorial nature of these tumors. Dr. Link also introduces molecular features, such as chromosomal alterations and mutations, and explains how they can help predict tumor behavior and potentially provide targets for therapy. He discusses the relevance of methylation classification and the potential impact of immunotherapy in meningioma treatment. Dr. Link concludes by emphasizing the importance of understanding the evolving landscape of meningioma and the potential for personalized treatment approaches based on molecular characteristics. The specific grading decisions are based on patient preferences and factors such as MIB1 levels and additional information obtained through molecular profiling.

Asset Subtitle

Ian F. Dunn, MD, FAANS

Keywords

meningioma

evolving understanding

pathology

grading system

molecular features

treatment