What is the Surgical Benefit of Utilizing 5-Aminolevulinic Acid (5-ALA) for Fluorescence-Guided Surgery of Brain Tumors?-On-demand Archive

Video Transcription

Video Summary

The video is a webinar about the surgical benefit of utilizing 5-ALA fluorescence-guided surgery for brain tumors. The presenter, Dr. Haja Panias, discusses the use and effectiveness of 5-ALA in visualizing malignant brain tissue during surgery. The webinar covers topics such as the metabolism of 5-ALA, experiments involving 5-ALA in vitro and in rodent models, the sensitivity and positive predictive value of 5-ALA fluorescence guidance, extent of resection, safety of 5-ALA, and the regulatory state of 5-ALA in the United States. Dr. Panias emphasizes the advantages of fluorescence-guided surgery, including real-time visualization of brain tumors, the ability to perform more extensive resections, and the potential impact on overall survival of patients with malignant gliomas. He discusses the different technologies used for fluorescence-guided brain tumor resection, including endocyanin green, fluorescein sodium, and 5-ALA. The video also addresses the challenges and limitations of 5-ALA fluorescence-guided surgery, such as false-positive and false-negative fluorescence, and the need for proper training in using the technology. The webinar concludes with a Q&A session, where Dr. Panias answers questions from the audience. The overall purpose of the webinar is to educate healthcare professionals on the benefits and limitations of using 5-ALA fluorescence-guided surgery for brain tumors.

Asset Subtitle

This program is 70 minutes.

Keywords

5-ALA fluorescence-guided surgery

brain tumors

Dr. Haja Panias

malignant brain tissue

extent of resection

safety of 5-ALA

advantages

real-time visualization

malignant gliomas

limitations

healthcare professionals