Young Neurosurgeons and Rapid Fire Abstracts-Creation of a Novel Mouse Model of Sporadic Cerebral Arteriovenous Malformations

Creation of a Novel Mouse Model of Sporadic Cerebral Arteriovenous Malformations

Video Transcription

Video Summary

In this video, Keean Peterson, a third-year medical student, discusses his research on cerebral arteriovenous malformations (AVMs). AVMs are abnormal connections between arteries and veins in the brain that can lead to hemorrhagic strokes. Peterson explains that the exact cause of AVMs is still unknown, but genetic predisposition, inflammation, trauma, and epigenetic influences are believed to play a role. He discusses the importance of the RAS-MAPK signaling pathway in the development of AVMs and how somatic mutations in this pathway are commonly found in vascular malformations. Peterson also explains his work on creating a novel mouse model of sporadic cerebral AVMs using specific genetic mutations. This model can help further research on understanding and treating AVMs.

Asset Subtitle

Keyan Peterson

Keywords

cerebral arteriovenous malformations

AVMs

hemorrhagic strokes

RAS-MAPK signaling pathway

somatic mutations