Young Neurosurgeons and Rapid Fire Abstracts-Inhibiting Complement Activation Prevents Severe Brain Injury and Post-Hemorrhagic Hydrocephalus in New Model of Germinal Matrix Hemorrhage

Inhibiting Complement Activation Prevents Severe Brain Injury and Post-Hemorrhagic Hydrocephalus in New Model of Germinal Matrix Hemorrhage

Video Transcription

Video Summary

The video discusses the impact of germomatrix hemorrhage (GMH) on post-hemorrhagic hydrocephalus. GMH is a severe disease affecting infants, with no current treatment options available. It is similar to traumatic brain injury (TBI) and stroke in terms of having primary and secondary injuries. The secondary injury involves inflammation and neuroinflammation. Previous studies have shown that complement inhibition can reduce the harmful effects of secondary injury in TBI and stroke, so the researchers aimed to test the same concept in GMH. They developed a neonatal mouse model and injected collagenase to mimic GMH. They found that inhibiting complement reduced the secondary injury and post-hemorrhagic hydrocephalus, improved brain preservation, hippocampus size, and survival rates. They plan to further investigate complement deposition, cellular targets, mechanisms of hydrocephalus development, and cognitive outcomes. The research has the potential for translation to human patients. No credits were mentioned in the video.

Asset Subtitle

Mohammed Alshareef, MD

Keywords

germomatrix hemorrhage

post-hemorrhagic hydrocephalus

infants

traumatic brain injury

stroke