Young Neurosurgeons and Rapid Fire Abstracts-Neutrophils Contribute to Intracranial Aneurysm Pathogenesis in an Estrogen-dependent Manner

Neutrophils Contribute to Intracranial Aneurysm Pathogenesis in an Estrogen-dependent Manner

Video Transcription

Video Summary

In this video, Devin Bitzell, a medical student working in Dr. Brian Ho's lab at the University of Florida, discusses a project titled "Neutrophils Contribute to Intracranial Aneurysm Pathogenesis in an Estrogen-Dependent Manner." The prevalence of intracranial aneurysms is between 3.6% and 6%, and their rupture can be life-threatening. Inflammatory pathways and sex hormones, particularly estrogen, are believed to play a role in aneurysm rupture. While the protective role of estrogen and the involvement of other inflammatory cells have been studied, the role of neutrophils remains unknown. In this study using a rabbit model, neutrophil depletion was found to reduce aneurysm rupture in estrogen-deficient females and decrease aneurysm formation in males. Further research is needed to understand how neutrophils contribute to aneurysm pathogenesis. Funding for the project was acknowledged along with the contributions of the lab members.

Asset Subtitle

Devan Patel

Keywords

neutrophils

intracranial aneurysms

estrogen-dependent

inflammatory pathways

rabbit model