Young Neurosurgeons and Rapid Fire Abstracts-Poliovirus Oncolytic Activity in Medulloblastoma is Mediated by Oxidative Stress

Poliovirus Oncolytic Activity in Medulloblastoma is Mediated by Oxidative Stress

Video Transcription

Video Summary

In this video, Eric Thompson discusses the oncolytic activity of the oncolytic poliovirus recombinant, PVS-RIPO, in medulloblastoma. He explains that they are currently enrolling patients in a phase 1b study of PVS-RIPO for recurrent malignant brain tumors in children. Thompson states that the objective of their study is to understand the molecular mechanism of how PVS-RIPO works in medulloblastoma to improve its efficacy. They found that PVS-RIPO effectively kills medulloblastoma in a dose-dependent manner and induces a profound oxidative stress response. They also demonstrate that pro-oxidants enhance the efficacy of PVS-RIPO while antioxidants decrease its effectiveness. The study is currently investigating the combination of pro- and antioxidants with PVS-RIPO in vivo. Thompson acknowledges funding from the DoD grant and Mussela Foundation.

Asset Subtitle

Eric M. Thompson, MD, FAANS

Keywords

PVS-RIPO

medulloblastoma

efficacy

oxidative stress response

combination therapy